Recent Advances in Drug Delivery To Posterior Eye

Omkar Kulkarni, Harsh Priya


Posterior eye segment diseases such as diabetic retinopathy, age-related macular degeneration, retinoblastoma, macular edema secondary to retinal vein occlusion, retinitis, etc. cause vision impairment and blindness to millions of people. Treatment and management of such diseases requires availability of therapeutic concentration in the posterior segment. However, anatomy and physiology of ocular barriers prevent efficient drug delivery to the posterior segment. The design of a drug-delivery system targeting the posterior segment is a challenging ophthalmological task. This review describes the recent progress of more efficient drug delivery technologies. Drug delivery systems that provide optimal pharmacokinetics, optimum dose intervals and significantly less invasive routes of administration are being produced. Solid lipid nanoparticles, nanostructured lipid carriers, submicron sized lipid emulsions and other colloidal nanoparticle carriers appear to be useful for enhancing the ocular absorption of drugs and for providing selective and prolonged drug concentration in the eye after topical instillation. In addition to this, Periocular drug delivery devices such as hydrogel contact lenses, implants that can deliver controlled and continuous biologics directly to the back of the eye and microneedles for targeted drug administration are being tested.


Posterior eye, Nanotechnology, Hydrogel lens, Implant

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Uday B. Kompella, Aniruddha C. Amrite, RashmiPacha Ravi, Shelley A. Durazo ‘Nanomedicines for back of the eye drug delivery, gene delivery, and imaging’ Progress in Retinal and Eye Research 36 (2013) 172-198

Heebeom Koo, Hyungwon Moon, Hyounkoo Han, JinHee Na, MyungSook Huh, Jae Hyung Park , Se Joon Woo, KyuHyung Park, Chan Kwon, Kwangmeyung Kim, Hyuncheol Kim ‘The movement of self-assembled amphiphilic polymeric nanoparticles in the vitreous and retina after intravitreal injection’ Biomaterials 33 (2012) 3485-3493

Marcelo L. Occhiutto, Fatima R. Freitas, Raul C. Maranhao and Vital P. Costa ‘Breakdown of the Blood-Ocular Barrier as a Strategy for the systemic use of Nanosystems’ Pharmaceutics 2012,4,252-275

Divya Gupta ‘Review on ocular drug delivery’

A. Urtti, L. Salminen ‘Minimizing systemic absorption of topically administered ophthalmic drugs’ Surv. Ophthalmol. 37 (1993) 435–457.

D.M. Maurice, S. Mishima, Ocular pharmacokinetics, in: M.L. Sears (Ed.), Handbook of experimental pharmacology, vol. 69, Springer Verlag, Berlin-Heidelberg, 1984, pp. 16–119.

D.H. Geroski, H.F. Edelhauser, Transscleral drug delivery for

posterior segment disease, Adv. Drug Deliv. Rev. 52 (2001) 37–48.

M. Hornof, E. Toropainen, A. Urtti, ‘Cell culture models of the ocular barriers’ Eur. J. Pharm. Biopharm. 60 (2005) 207–225.

Lin Ying, KoheiTahara, Hirofumi Takeuchi ‘Drug delivery to the ocular posterior segment using lipid emulsion via eye drop administration: Effect of emulsion formulations and surface modification’ International Journal of Pharmaceutics 453 (2013) 329– 335

KoheiHironaka, YutaInokuchi, Yuichi Tozuka, MasamitsuShimazawa, Hideaki Hara b, Hirofumi Takeuchi ‘Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye’ Journal of Controlled Release 136 (2009) 247–253

Joana Araújoa, Sasha Nikolica, Maria A. Egeaa, Eliana B. Soutoc,d, Maria L. Garciaa ‘Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye’ Colloids and Surfaces B: Biointerfaces 88 (2011) 150– 157

Z.R. Huang, S.C. Hua, Y.L. Yang, J.Y. Fang, ‘Development and evaluation of lipidnanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion’Acta. Pharmacol. Sin. 29 (2008) 1094–1102.

H.Z. Bu, H.J. Gukasyan, L. Goulet, X.J. Lou, C. Xiang, T. Koudriakova, ‘Oculardisposition, pharmacokinetics, efficacy and safety of nanoparticle-formulated ophthalmic drugs’ Curr. Drug Metab. 8 (2007) 91–107.

Creech, J. L.; Chauhan, A.; Radke, C. J. ‘Dispersive mixing in theposterior tear film under a soft contact lens’Ind. Eng. Chem. Res. 2001,40, 3015-3026.

Chi-Chung Li and Anuj Chauhan ‘Modeling Ophthalmic Drug Delivery by Soaked Contact Lenses’ Ind. Eng. Chem. Res. 2006, 45, 3718-3734

Takeaki Kawashima, Nobuhiro Nagai, HirokazuKaji, NorihiroKumasaka, Hideyuki Onami,Yumi Ishikawa, Noriko Osumi, MatsuhikoNishizawa, Toshiaki Abe ‘A scalable controlled-release device for transscleral drug delivery to the retina’ Biomaterials 32 (2011) 1950-1956


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